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Title: 2nd Preclinical Models Imaging Workshop

Dates: 10-14 October 2022

Duration: 5 days

Venue: Congress Center of NCSR Democritus (theoretical part) & BIOEMTECH Laboratories (practical part) Agia Paraskevi, Attica, Greece

Organizers: BIOEMTECH Laboratories

  • ➢ Maritina Rouchota, PhD, Partner & Lab Director
  • ➢ Argyro Zacharioudaki, DVM MLAS DiplECLAM, Veterinarian & In-vivo
    Research Consultant

Fees:

  • ➢ 950 € Individual (after August 25th)
  • ➢ 800 € Early bird (20% discount for payments completed until August 31st!)
  • ➢ 750 € Student (requiring documentation for student status)
  • ➢ 450 € Virtual -theoretical part- for overseas attendees (non-Europe based)

Registration:During September 2022 @ https://forms.office.com/r/hjuNLMzvSC

Contact: info@bioemtech.com

Website: https://bioemtech.com/portfolio/2nd-preclinical-models-imaging-workshop/

Description: This workshop aims to present theoretical and practical aspects of preclinical
models’ imaging. The workshop provides a general overview of licensing and
operating an imaging facility for rodent models, as well as specific details for
selecting and applying imaging modalities for various models. The practical part
offers training in mouse handling for imaging projects and operating imaging
equipment.
Places for practical training will be reserved on a first come, first-served basis.
Only inanimate models will be used for training.

Register Here


Theoretical Part

Day 1: Monday, 10 October 2022

Session: Imaging Technologies

08.30 – Registration | Secretariat

09.00 – Welcome (15’) | M Rouchota, BIOEMTECH

09.15 – NCSR & BIOEMTECH (45’) | G Loudos, CEO of BIOEMTECH

10.00 – Translational research and EMA/FDA applications (60’) | I Allen, Allen Consulting and Management

11.00 – Coffee break

Session: Imaging Technologies

11.30 – Optical (30’) | I Zacharakis, IESL-FORTH

12.00 – Ultrasound (30’) | S Tsantis, Univ.of West Attica

12.30 – MRI (30’) | F Schilling, Technische Universität München

13.00 – Lunch break

14.00 – PET-CT (30’) | N Karakatsanis, Weill Cornell Medical College

14.30 – SPECT (30’) | S Vandenberghe, Univ.of Gent

15.00 – Multimodal post-processing (60’) | TBA

16.00 – Coffee break

Session: The Preclinical Laboratory

16.30 – Goal & operation of a preclinical laboratory (45’) | A Sorace, University of Alabama at Birmingham


Day 2: Tuesday, 11 October 2022

Session: Animal Use

09.00 – Legislation & ethics (EU Modules 1,2) (30’) | A Zacharioudaki, BIOEMTECH

09.30 – Mouse biomethodology (EU Modules 3.1,4,6.1,7&20) (60’) | A Zacharioudaki, BIOEMTECH

10.30 – Coffee break

11.00 – Welfare assessment & humane endpoints (EU Module 5) (30’) | L Whitfield, Owlvets

11.30 – Animal welfare considerations and impact on imaging studies (30’) | J Lopez-Tremoleda, Queen Mary Univ. of London

12.00 – Communication, SOPs and health considerations (30’) | V Ntafis, BSRC Al.Fleming

12.30 – Lunch break

Session: Radiolabelling & Radioprotection

13.30 – Double isotopes for therapy and diagnosis (30’) | O Keinänen, Hunter College of the City University of New York

14.30 – Radiolabeling for rodent imaging (30’) | E Lambidis, BIOEMTECH

15.00 – Coffee break

15.30 – Radiation protection in the preclincial imaging laboratory (30’) | M Bernsen, Erasmus MC

16.00 – a-emitters for therapy (30’) | B Cagle, Viewpoint

16.30 – Imaging of a-emitters (30’) | I Tworowska, Radiomedix


Day 3: Wednesday, 12 October 2022

Session: Preclinical Models

09.00 – Oncology models (60’) | T Karampelas, BIOEMTECH

10.00 – Lung Fibrosis Model (30’) | L Ntari, BIOEMTECH

10.30 – Coffee break

11.00 – Heart failure with reduced ejection fraction in diabetic cardiomyopathy and ventricular pressure overload mouse models (60’) | D Catalucci, IRGB-CNR

12.00 – Lunch break

13.00 – Myocardial infarction models (60’) | I Mourouzis, National & Kapodistrian Univ. of Athens

14.00 – Sample collection and analysis ex-vivo (60’) | A Tsingotjidou, Aristotle Univ. of Thessaloniki

19.30: Workshop Dinner at Athens Riviera (place TBA soon!)


Practical Part

Day 4: Thursday, 13 October 2022

Session: Practical training rotation (groups of 4, each participant is trained in all stations at a different order)

@ BIOEMTECH Laboratories

09.00 (2h) – Animal preparation 1: substance administration using mimicky mouse

11.00 – Coffee break

11.30 (2h) – Animal preparation 2: anesthesia & imaging set-up using mimicky mouse

13.30 – Lunch break

14.30 (2h) – Image quantification examples and practice


Day 5: Friday, 14 October 2022

Session: Practical training rotation (each participant is trained all stations in a different order)

@ BIOEMTECH Laboratories

09.00 (2h) – CT, SPECT imaging using the mouse phantom model

11.00 – Coffee break

11.30 (2h) – β-eye, γ-eye, φ-eye imaging using the mouse phantom model

13.30 – Lunch break

14.30 (2h) – Image extraction examples and practice

16.30: Closing Reception at Congress Center

Invited Speakers & Laboratories

Irving Coy Allen, MBA, PhD; President and Managing Partner; Allen Consulting and Management, LLC; icallenconsulting@gmail.com

Dr. Irving Coy Allen has an MBA in Bioscience Management, and a Ph.D. in Genetics and Molecular Biology. Currently, he has the position of the associate professor at the Department of Biomedical Sciences and Pathobiology Virginia-Maryland College of veterinary Medicine Virginia Tech Blacksburg. He has various research interests such as Cancer immunology, Animal models of innate immunity, animal models of allergic disease, host pathogen interactions, among others.


Monique Bernsen, PhD; Head AMIE Core Facility; Assistant Professor Molecular Imaging; Erasmus MC, Rotterdam the Netherlands m.bernsen@erasmusmc.nl

Dr. Monique R. Bernsen has a Ph.D. degree in the field of Tumor Immunology. She, currently, works at the Dept. of Radiology & Nuclear Medicine, Erasmus MC. Dr. Monique does research in preclinical, molecular imaging. Present research topics involve projects in the field of cell tracking, tumor characterization and drug delivery. Imaging modalities that are being used include magnetic resonance imaging, positron emission tomography, single photon emission tomography and optical imaging, among others.


Brianna Cagle, Ph.D.; Assistant Research Scientist, Viewpoint | Brianna-Cagle@viewpointmt.com

Dr Cagle is an Assistant Research Scientist at Viewpoint Molecular Targeting. She studied her BS Chemistry; Biology Minor with Honors – University of Missouri-Kansas City and continued with her Ph.D. in Pharmaceutical Sciences and Experimental Therapeutics – University of Iowa. Currently she is involved in the non-clinical research and development of alpha-targeted peptide pharmaceuticals for cancer therapy and diagnostics, using the true theragnostic pair 203/212Pb which allows imaging with 203Pb, and alpha-particle therapy with 212Pb which has an improved tumor response as compared to beta-particle therapy.


Daniele Catalucci, PhD; National Research Council (CNR), Institute of Genetic and Biomedical Research (IRGB) and Humanitas Research Hospital, Milan, Italy daniele.catalucci@cnr.it

Dr. Daniele Catalucci graduated from the University of Rome − Roma Tre, in 1999 and received his PhD in molecular and cellular biology from the University of Rome − Tor Vergata, in 2003. Supported by a Marie Curie Outgoing International Fellowship, he performed his postdoctoral studies at the Department of Medicine, University of California San Diego, USA. By the end of 2007, Dr. Catalucci moved back to Italy (Milan) where he started up his own group at the Institute of Biomedical Technologies of the National Research Council (ITB-CNR) in collaboration with the IRCCS Multimedica Hospital. In 2009, he became a tenured scientist at the Institute of Genetic and Biomedical Research (IRGB) of CNR and in 2012, his laboratory moved to the Humanitas Research Hospital. His lab aims to dissect the molecular mechanisms underlying cardiac diseases, to increase the knowledge about the function of the physiologic vs pathologic heart, and to develop novel and more effective therapeutic approaches for the treatment of the failing heart.


Eliza Lambidis – Radiochemist at BIOEMTECH | eliza.lambidis@bioemtech.com

Eliza, radiochemist at BIOEMTECH’s, is conducting analytical and R&D experiments using various materials, from small precursors to antibodies and nanoparticles, and radiometals, such as Ga-68, In-111 and Lu-177. Her undergraduate (BSc, University of Bath, UK) and Master’s degrees (MRes, Imperial College London, UK) are in chemistry and bioimaging sciences. She has participated in bioinorganic and analytical chemistry as well as molecular biology research projects and obtained her second Master’s degree (MPhil, Hong Kong Baptist University, HK SAR), carrying out chemistry research projects, on organic synthesis and photophysical measurements of theranostic agents. During her PhD (University of Helsinki), she conducted research in radiopharmaceutical chemistry and synthesised radiotracers and theranostics for both PET and SPECT imaging applications.


Jordi Lopez-Tremoleda, DVM, MSc, PhD, MRCVS; Reader in Animal Science & Welfare / Named Veterinary Surgeon and Welfare Officer; Blizard Institute. Barts and the London School of Medicine and Dentistry. QMUL. London | j.lopez-tremoleda@qmul.ac.uk

Jordi’s most recent professional experience is a Reader in Animal Science & Welfare and the Named Veterinary Surgeon and Welfare Officer at QMUL in London, where he manages the study design, execution, analysis, and reporting of complex polytrauma and CNS injury models along with all the NVS duties on animal welfare, health, and bioethics. Prior to this, he coordinated the preclinical research at the Biological Imaging Centre at Imperial College London for various years, following on a fellowship on stem cells-based technology at the MRC Centre for Regenerative Medicine at Edinburgh University. He holds a PhD in Reproductive Biology from Utrecht University, an MSc in Bioethics & Law from the University of Barcelona, MSc in Education for QMUL and a degree in Veterinary Medicine from the Universitat Autonoma de Barcelona. He is an active member of LAVA, LASA, ESLAV and AWERB at QMUL, PUCP (Peru) and previously at ICL. He is an editor-in- chief for Laboratory Animals. He is currently enrolled for the ECLAM alternative residency.


Iordanis Mourouzis, MD, PhD; Associate Professor of Pharmacology; Dpt of Pharmacology, Medical School, National and Kapodistrian University of Athens; imour@med.uoa.gr

Dr.  Mourouzis received his degree in Medicine from University of Athens (2001) and PhD in “Thyroid hormone and cardioprotection” (2006, University of Athens). He is a trained cardiologist and is currently Associate Professor in the Department of Pharmacology, Medical School, University of Athens. He has considerable experience in experimental models of isolated rat hearts, in vivo model of ischemia-reperfusion, echocardiography in mice and rats, biochemical and molecular techniques. His research is focused on the role of thyroid hormone in tissue repair/regeneration (myocardium, neural tissue, pancreas, sepsis) and especially on endogenous mechanisms of repair/regeneration after myocardial injury. This research has resulted in a Phase II clinical trial (Thy-Repair) testing the effects of T3 in patients with acute myocardial infarction (EudraCT:2016-000631-40). Dr. Mourouzis has published more than 115 scientific papers in international, peer-review journals. His work has received more than 3900 citations according to Google Scholar (h-index 38).

Iordanis Mourouzis

Nikolaos Karakatsanis, PhD, DABSNM- Assistant Professor of Biomedical Engineering in Radiology at Weill Medical College of Cornell University | nicolas.karakatsanis@gmail.com

Dr. Nikolaos A. Karakatsanis is currently Assistant Professor of Biomedical Engineering in the Radiology Department of Weill Cornell Medical College, Cornell University in New York, NY, USA. He has also been appointed as Adjunct Assistant Professor at the Biomedical Engineering and Imaging Institute (BMEII) of the Icahn School of Medicine at Mouth Sinai, New York. Dr Karakatsanis is certified from the American Board of Science in Nuclear Medicine (ABSNM) with a specialty in Nuclear Medicine Physics and Instrumentation. Nicolas is also a Senior IEEE member and elected (3-year term, 2017-2020) in the Nuclear Medical Imaging Sciences Council (NMISC) of the IEEE Nuclear and Plasma Sciences Society (NPSS). Moreover, Nicolas has served as the elected intern (2-year term, 2017-2019) of the Computer and Instrumentation Council of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

Nikolaos Karakatsanis

Outi Keinänen, PhD; Research Fellow, Hunter College of the City University of New York, NY, USA; University of Helsinki, Helsinki, Finland; Memorial Sloan Kettering Cancer Center, New York, NY, USA | okeinane@gmail.com

Dr. Keinänen gained her PhD diploma in 2018 from the University of Helsinki, Finland. Her thesis supervisors were Dr. Anu Airaksinen and Dr. Mirkka Sarparanta. Outi started her postdoctoral training under the supervision of Dr. Brian M. Zeglis in 2018 at Hunter College of the City University of New York. Recently, she received the NIH Pathway to Independence Award (K99/R00).


Vasileios Ntafis, DVM, MSc, PhD, Staff Scientist B’, Head-Designated Veterinarian, Animal Facilities, BSRC “Alexander Fleming” ntafis@fleming.gr

Vasileios Ntafis is a Doctor of Veterinary Medicine with a PhD in “Virology and Viral Diseases”. Since 2012, he is the Head and designated veterinarian of the Animal Facilities of BSRC “Alexander Fleming”, located in Athens, Greece. In parallel, in 2017 he was elected to the position of Research Scientist, with his interests focusing on the development of phenotyping assays for small rodents. He is currently responsible for the operation of the In vivo Imaging Unit of Fleming, and he is actively involved in the development of imaging methods for mice, using x-rays, bioluminescence, fluorescence, endoscopy and ultrasound technologies. Currently, he is the President of the Hellenic Society of Biomedical and Laboratory Animal Science (HSBLAS) and member of the Governing Board of the European Society of Laboratory Animal Veterinarians (ESLAV).


Lydia Ntari, PhD, Project Manager, BIOEMTECH | lntari@bioemtech.com

Dr. Lydia Ntari, currently serves as α Project Manager at BIOEMTECH. She obtained her bachelor’s degree in Biological Studies with Honours in Medical Biology from the University of Edinburgh and her MSc in Reproductive science and Women’s Health from University College London. She has a Ph.D. in inflammation and ageing from the Medical School of Crete University. Dr Lydia Ntari has worked as a Research and Development scientist at Biomedcode S.A. Hellas and as a Research Associate at the Laboratory of Biology of the Medical school of the National and Kapodistrian University of Athens. She has been working with various animal models and diseases for more the last 8 years and has a significant record in preclinical projects management.


Franz Schilling, Assistant Professor (TT) bei Technische Universität München | fschilling@tum.de

Dr. Franz Schilling studied physics at the University of Würzburg and the University of California (Berkeley). He obtained a PhD from TUM focusing on nuclear magnetic resonance. During postdoctoral research at the University of Cambridge he deepened his interest for molecular imaging. Since 2017 he leads an independent research group at the Klinikum rechts der Isar at TUM. In 2019 he was appointed Assistant Professor for Biomedical Magnetic Resonance at TUM.

Franz Schilling

Anna Sorace, Ph.D.; Assistant Professor, Department of Radiology and Biomedical Engineering; Director, Small Animal Imaging Shared Facility University of Alabama at Birmingham asorace@uabmc.edu

Dr. Anna Sorace has a bachelor’s degree in Biological Engineering from Mississippi State University and an M.S. and a Ph.D. in Biomedical Engineering from University of Alabama. Currently, she serves as an assistant professor at Alabama University. She, also, served as an assistant professor at the University of Texas at Austin in 2019 in the Departments of Diagnostic Medicine, Oncology, and Biomedical Engineering. Her broad research interests include improving cancer patient care through translational advancements in cancer imaging. She has expertise in multimodality, non-invasive quantitative imaging to improve detection, monitoring and therapy of cancer in both preclinical animal models and clinical cancer research.

Anna Sorace

Stavros Tsantis, “General Manager – Rhodes General Hospital ‘Andreas G. Papandreou’ | stsantis@uniwa.gr

Dr. Stavros Tsantis received his Diploma in Biomedical Engineering from Technological Educational Institute of Athens, MSc in Biomedical Instrumentation Engineering, from University of Dundee, PhD in Medical Physics in the department of Medical Physics University of Patras, and MSc in Health Management from National School of Public Health. He has worked as a Biomedical Engineer in GENERAL HOSPITAL OF ELEYSIS ‘THRIASSIO’, as Head of Biomedical Engineering Department in HEALTH DISTRICT OF PIRAEUS AND AEGEAN, ATHENS, GREECE. Currently he is a research fellow at University of Western Attica, while recently, he took over as the new General Manager of Rhodes Hospital ‘Andreas G. Papandreou’


Anastasia Tsingotjidou– D.V.M., Ph.D. at Lab of Anatomy and Histology astsing@vet.auth.gr

Dr. Anastasia Tsingotjidou is an Assistant Professor (with tenure) Laboratory of Anatomy, Histology and Embryology School of Veterinary Medicine, AUTh.  She has a Ph.D. in Neuroanatomy, Lab. of Anatomy, Histology and Embryology School of Veterinary Medicine, AUTh and a bachelor’s degree in Veterinary Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki (AUTh).

Anastasia Tsingotjidou

Stefaan Vandenberghe- Research Professor-Editor in Chief EJNMMI Physics-BAEF fellow 2004 | Stefaan.Vandenberghe@UGent.be

Stefaan Vandenberghe obtained his MSc in Physics and an additional degree in Biomedical Engineering from KU Leuven. After working in the nuclear medicine department of the University Hospital Ghent he started a Ph.D. in the MEDISIP group of the University of Ghent. His research was on the optimal configuration of gamma cameras for PET imaging and on list-mode reconstruction techniques for PET systems. He received a Ph.D. (Engineering) from this university. for PET Currently, he is a Research Professor at Ghent University while his main Research working is on Total body TOF PET, PET-MRI, Monte Carlo simulation and image reconstruction for PET and SPECT. He manages both development of new systems and reconstruction methods.

Stefaan Vandenberghe

Lucy Whitfield, Dr Lucy Whitfield MA VetMB DLAS PGCert (VetEd) FHEA MRCVS; Director, OWL Vets Ltd, UK | lucy@owlvets.com

Lucy Whitfield has o obtained her degree in Veterinary Medicine from University of Cambridge and she currently serves as a director at OWL Vets Ltd. With more than 20 years’ experience of leadership in laboratory animal welfare and medicine, her passion is to educate, communicate and help others to safeguard the humane use of animals where they are necessary in research, through education, training, and clinical services. She is highly skilled at Clinical laboratory animal medicine, ethical review of protocols, leadership and financial management, design and creation of learning materials, pharmacovigilance and facility audit and report.


Isabella Tworowska- Chief Scientific Officer at RadioMedix Inc. | itworowska@radiomedix.com

Co-founder of RadioMedix and is leading the radiotherapeutic program starting from the drug discovery to the clinical studies. Originally trained as a clinical pharmacist and organic chemist, Dr. Tworowska completed her PHD training at the Polish Academy of Science and Frankfurt University with postdoctoral fellowship at Rice University, in Houston, TX. She received the International Sigma-Aldrich Award and International Union and Pure and Applied Chemistry Award. Dr. Tworowska publishes in peer-reviewed journals and serves as a member on the NIH panel reviews, NCI radiotherapy groups and journal editorial boards. She oversees all RadioMedix activities related to commercialization of AlphaMedix™ and is responsible for its development (Phase II SBIR Contract)


Ioannis Zacharakis – Principal Researcher at FORTH – IESL | zahari@iesl.forth.gr

Dr. Giannis Zacharakis is a Principal Researcher at the Institute of Electronic Structure and Laser – Foundation for Research and Technology (FORTH – IESL) and the Head of the Laboratory for Biophotonics and Molecular Imaging. He has served as the Vice President (2018 -2019) and President (2019-2020) of the European Society for Molecular Imaging (ESMI) and he has served two terms as a Member of the Council of the same Society (2014-2018). He is also the elected vice-president of the board of researchers at FORTH. He has a degree in Physics and a PhD in Biomedical Imaging from the University of Crete. During 2003 and 2004 he has been a Research Fellow in Radiology at Harvard University, Cambridge MA USA.


Argyro Zacharioudaki, DVM, MLAS, DiplECLAM, Veterinarian and in-vivo Research Consultant, BIOEMTECH | azacharioudaki@bioemtech.com

Graduated from the Veterinary Faculty of the Aristotle University of Thessaloniki, Greece. Holds a Master of Laboratory Animal Science (MLAS, University of Copenhagen) and a Postgraduate Certificate in Veterinary Education (FHEA, RVC). Qualified by examination as Diplomate of the European College of Laboratory Animal Medicine (Dipl.ECLAM) and EBVS European Veterinary Specialist in Laboratory Animal Medicine. Employed for almost 14 years as the Designated Veterinarian of the Experimental Educational Research Center ELPEN (EERCE), Athens, Greece. Currently employed as a research veterinarian and in-vivo research consultant at BIOEMTECH Laboratories, Athens, Greece. Serves as General Secretary and webmaster of Hellenic Society of Biomedical and Laboratory Animal Science (HSBLAS), and Coordinator of the LAS EU Functions Course.

Argyro Zacharioudaki

Maritina G. Rouchota- Partner & Lab Director at BIOEMTECH / Preclinical CRO & Imaging systems | mrouchota@bioemtech.com

Dr. Maritina Rouchota is a radiation Physicist with professional certifications on the design and implementation of pre-clinical studies, use of radiation in clinical and pre-clinical procedures and certified Radiation Protection Expert (RPE). Dr. Rouchota is a Partner, Lab Director, and Application Specialist at BIOEMTECH. She has served as an associate researcher at UNIWA from 2015 to 2017. She obtained a bachelor’s degree at Physics, Nuclear and Particle Physics Stream from National and Kapodistrian University of Athens, a master’s degree in Medical Physics and Bioengineering from UCL University and her Ph.D. in Molecular Imaging from the University of Patras. She currently leads the lab CRO activities of BIOEMTECH and a team of 10 lab scientists.

Maritina G. Rouchota

George Loudos- co-founder and CEO at BIOEMTECH| george@bioemtech.com

Dr. George Loudos is the CEO and co-founder of BIOEMTECH. He received his Diploma in Electrical Engineering and Ph.D. in Biomedical Engineering from National Technical University of Athens and has served as an assistant Professor of Biomedical Engineering at UNIWA for 13 years. He has a long successful record of multidisciplinary scientific projects and of significant funding attraction.  He has inspired the “eyes,” the first desktop imaging systems that provide real time imaging of both PET/SPECT isotopes, as well as fluorescent bioluminescent dyes and currently leads a company of 25 people.

loudos

Thodoris Karampelas Research Development & Quality Assurance Manager | tkarampelas@bioemtech.com

Thodoris is a biotechnologist by training and holds a PhD in Pharmacology. He has been working on research associated with drug discovery and especially in the field of targeted anticancer agents, for more than 12 years. He has been involved in numerous drug discovery projects, academic and industrial, and in all the various stages that this multidimensional process requires (from target validation to lead optimization and exploration of IP potential). Ηe participated in the maintenance of an ISO17025 accreditation for the analysis of samples deriving from clinical trials. This helped him built important experience regarding operation in a regulated environment and bioanalytical tasks that are governed by EMA/OECD guidelines. In BIOEMTECH, he is responsible for the overview and maintenance of BIOEMTECH Laboratories Quality System that is based on Good Laboratory Practice (GLP), he co-ordinates various preclinical projects and he participates in the company’s efforts to enrich its research portfolio and activities through participation in interdisciplinary collaborative schemes.


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