BIOEMTECH introduces the first generation of fillable mouse and rat phantoms, designed for nuclear medicine (PET/SPECT) applications, but already successfully tested for X-ray (CT), Magnetic Resonance Imaging (MRI), Optical Imaging (OI) and Magnetic Particle Imaging (MPI).

• The fillable phantoms allow easy and reproducible evaluation of preclinical imaging systems and assessment of demanding imaging protocols. They are easily filled with any radioisotope, fluorescent dye, contrast agent or nanoparticle, providing a very good model of rodents’ geometry, which cannot be approached using standard phantoms.
• The fillable phantoms allow an accurate simulation of complicated experimental setups, without the need to use actual rodents. All costs related to animal use and preparation, order and use of radiopharmaceuticals and contrast agents suitable for animal administration are minimized, since pure isotopes or other compounds can be used to mimic an animal study, at known concentrations.
• Very specific biodistributions and kinetics can be extensively studied, without the arbitrariness related to a living animal. Besides its practical value, the fillable phantoms are in compliance with bioethics and 3Rs principle!
• For imaging companies, the fillable phantoms can be a “gold standard” to evaluate their systems under realistic imaging conditions.

• The fillable mouse phantom is based on Digimouse, published by Dogdas et al in 2007.

• It is a model of a 28g mouse extracted from anatomical and cryosection data.

• The material is compatible to tissue and non sensitive to magnetic fields.

• It contains major organs (brain, thyroid, heart, liver, kidneys, bladder) and two tumors.

• All organs/tumors can be easily, separately filled with isotopes.

• The rat phantom is based on a modification of the same model.

• Different sizes and animal positions are possible, upon request.

• Study very specific biodistributions without the arbitrariness related to a living animal.
• Reproducible assessment of different imaging protocols, using known concentrations
• Establishment of protocols for less frequently used isotopes
• Assessment of collimator penetration or positron range that deteriorate imaging quality
• Optimization of protocols for multiple isotope imaging
• Detection of low activities at the presence of high concentration in nearby organs
• Effect of different ratios between organs/tumors on the imaging performance
• Optimization of protocols for multiple simultaneous mouse imaging
• Evaluation of image reconstruction and correction algorithms.

Relevant Publications