Highly sensitive, benchtop, in vivo optical imaging system for Fluorescence and Bioluminescence preclinical studies
Features
- Small animal, whole body, live optical-imaging platform
- Fluorescence and Bioluminescence – Suitable for Cherenkov imaging (CLI) studies
- Extension to SWIR imaging
- Up to 5 mice simultaneous imaging
- Compatible with 3rd party anesthesia and vital signs monitoring systems
Performance
- High Quantum Efficiency of 85% at 460nm / 70% at 600 nm / 30% at 900 nm
- Dark current down to 0,016 e/pixels/sec
- Ultimate performance for low-signal applications
- Resolution of 4,6 μpixel – 4096 x 2304
- Readout noise as low as 0,3 electrons (rms)
- Photon number resolving imaging / Quantitative CMOS
- Weight less than 70kg
- Dimensions: 60cm (L) x 53cm (W) x 60cm (H)
Definition of a user friendly platform
- Straightforward workflow with easy imaging protocol set-up
- Plain to operate by non highly-experienced professionals
- User exchangeable optical filters thanks to BIOEMTECH’s unique filter cassettes concept
- Footprint allowing for simple system installation and transfer
- Ideal for imaging inside a clean room
- Visual | eyes™ software hub for post processing of imaging data
Applications
Inflammation, FLI
Bone imaging using the φ-eye™
In vivo fluorescence bone imaging using a probe with an emission wave length of 680nm, in a mouse model with spondyloarthritis. This method could be a powerful tool for monitoring disease progression and evaluating the efficacy of new therapeutic interventions.
Applications
SWIR, FLI
Healthy mouse imaging in the SWIR window
With BIOEMTECH technology imaging in the Short Wavelength InfraRed (SWIR) window is possible. In this image we can clearly distinguish the saphenous vein of a healthy mouse. Image info: Indocyanine Green (ICG) dye - Injected volume 100μL - Injected concetration 500μM - Time point 1min p.i. - Exposure time 5ms.
Applications
Oncology, FLI
Tumor imaging using the φ-eye™
tdTomato is a basal (constitutively fluorescent) orange fluorescent protein with excitation wavelength~554nm and emission wavelength~581nm, that can be used for tumor imaging. Here is an example in a neurofibroma model, using tdTomato dye intravenously administrated.
Applications
Oncology, FLI
Studying Epidermoid Carcinoma
Case study of in vivo therapy evaluation and staging of Epidermoid Carcinoma (also named Squamous cell carcinoma) in preclinical models using Fluorescence Optical Imaging. RFP dyes used.
Applications
Oncology, BLI
Tumor imaging with a bioluminescent dye
Use of D-Lusiferin as a bioluminescence reporter in a non-orthotopic glioblastoma tumor. Image info: Injected concentration 3mg - Injected volume 200μL - Acquisition time 30min
Looking for more info on the φ-eye™ and its applications?
Download the φ-eye™ Brochure