A desktop preclinical 3D SPECT platform for fast in vivo screening and longitudinal imaging of gamma- and alpha-emitting radiopharmaceuticals
From fast planar imaging to dynamic 3D SPECT
The γ-eye™ system now supports tomographic 3D SPECT imaging, enabling enhanced spatial assessment while preserving its compact footprint and simplicity
- 3D SPECT imaging for whole-body spatial assessment of radiopharmaceutical distribution and longitudinal evaluation across different time points
- 4D dynamic SPECT imaging, enabling quantitative kinetic analysis of radiotracer uptake
- Fast planar imaging for simple and time-efficient screening, such as the assessment of whole-body distribution and compound kinetics
- High-throughput imaging of up to four mice simultaneously or one rat*
*Available only for planar imaging
From multi-angle acquisition to 3D SPECT
The γ-eye™ uses fast 360° rotation to acquire whole-body projections from multiple angles, enabling tomographic 3D SPECT reconstruction with short acquisition times.
- Multi-angle whole-body acquisition over 360°, with planar projections acquired every 5°
- 3D SPECT reconstruction from 72 acquired projections, providing volumetric information in multiple anatomical planes
- Dynamic 4D SPECT imaging, with sequential reconstructed volumes to follow radiotracer kinetics over time
High-throughput imaging for multi-animal screening
The γ-eye™ is also available in a High Throughput configuration, designed for efficient planar imaging of larger study cohorts while preserving the core functionality of the standard system
- Field of view of 100 × 200 mm, providing extended coverage for multi-animal imaging
- Planar imaging of up to 4 mice simultaneously or 1 rat, supporting efficient screening workflows
- High-throughput performance of more than 110 mouse scans per day, increasing daily imaging capacity for larger study cohorts
Technical performance in a desktop format
- State-of-the-art detector architecture and components
- < 1.6 mm spatial resolution
- Down to 1 sec frames for whole-body planar imaging and 5 min frames for whole-body 3D SPECT imaging
- Energy resolution down to 11%
- Detectable energy range of 35-440 keV
- Available with 2 user-interchangeable collimators for different imaging requirements
- Compatible with 3rd party anesthesia and Vital Signs monitoring system
Applications
Oncology, beta emitters
Longitudinal low-activity 3D SPECT imaging of ¹⁷⁷Lu-Trastuzumab
Following radiopharmaceutical distribution over time, even as available activity decreases
Image info: longitudinal imaging from 2 to 120 h p.i. – 30 min scans – injected activity 0.4MBq – activity during imaging down to 0.11 MBq
Study performed in BIOEMTECH Laboratories
Applications
Oncology, alpha emitters
Longitudinal multi-window 3D SPECT imaging of ²²⁵Ac-Trastuzumab
Combining multiple energy windows to assess radiopharmaceutical distribution under reduced-count conditions
Image info: 48 h post injection - 30 min scan duration - 172kBq injected activity
Study performed in BIOEMTECH Laboratories and presented at TERACHEM 2026Applications
Oncology, beta emitters
Dynamic 4D SPECT imaging of ¹⁷⁷Lu-Trastuzumab
Early whole-body distribution and 3D SPECT imaging across higher- and lower-activity conditions
Image info: 3-53 min post injection - 5 min frame duration – 40.2 MBq activity during imaging
Study performed in BIOEMTECH Laboratories
Applications
Planar imaging
Extending SPECT workflows with fast planar imaging
Fast whole-body planar imaging for rapid assessment of radiopharmaceutical distribution and early kinetics across a broad range of radionuclides
Image info: ⁹⁹ᵐTc-labelled GRPR-targeting peptide in a PC-3 xenograft model - 0-60 min post injection - down to 10 sec frames - 30 MBq injected activity
Study performed in collaboration with the Radiopharmaceutical Chemistry Group at INRASTES, NCSR "Demokritos" (Dr. Ioannis Pirmetttis) and NuclearPharm
Applications
Theranostics
Evaluation of preclinical quantitative imaging of ¹¹¹Ag
Optimization and validation in a mouse phantom
Study was conducted in collaboration with Mattia Asti and the AUSL-IRCCS Reggio Emilia research team.
Applications
Quantification phantom studies across multiple radionuclides
Mouse phantom studies demonstrating the ability of γ-eye™ to image and quantify a broad range of diagnostic and therapeutic radionuclides across isotope-specific energy windows.
Studies performed in BIOEMTECH Laboratories
