Title: Preclinical Models Imaging Workshop

Date: 18-22/23 October 2021

Duration: 4-5 days

Registrations: extended until October 14 (cancellation fee: 50€)

Fees:

  • ➢ Theory only (online videoconference, max 50 places): 150€
  • ➢ Theory & practice (max 30 places, theory online – practice on-site): 250€

Register Here

COMULIS Scholarships available! *

Theory fees include virtual attendance, access to course materials and dinner night for participants located in Attica at the time. Practice fees include attendance of the practical session, access to additional course materials and light lunch.

At the end of the registration period participants will be notified if they have secured a place for the practical training session and if they are selected for the scholarship, and billing instructions will be forwarded.

*Scholarships: COMULIS announces 10 scholarships, 5 for theory only and 5 for theory & practice attendance option. Scholarships will cover attendance fee or attendance fee and travel expenses respectively. To apply please submit a 200-300-word motivation letter stating your reasons to participate and the expected benefits of your related scientific work during the application process.

Contact: For enquiries and scholarship applications contact azacharioudaki@bioemtech.com

Local Organizers (BIOEMTECH Laboratories): Dr. Argyro Zacharioudaki (AZ), Dr. Maritina Rouchota (MR), Irinaios Pilatis (RP), Prof. George Loudos (GL)

Description:

This workshop aims to present theoretical and practical aspects of preclinical models’ imaging. The workshop provides a general overview of licensing and operating an imaging facility for rodent models, as well as specific details for selecting and applying imaging modalities for various models. The (optional) practical part offers training in mouse handling for imaging projects and operating imaging equipment.


Preliminary Program (hours refer to CET!)

Day 1 (Monday 18/10/2021): Organizing Imaging Projects

09.00 CET   Welcome & Ιntroduction (G Loudos & COMULIS Coordinator)

09.10 CET   Preclinical imaging facility: goal & operation (20’ – M Rouchota)

09.30 CET   Preclinical project management (30’ – C Berthet)

10.00 CET   Imaging as a refinement tool (30’ – G Loudos)

Coffee break

Imaging technologies and applications (90’)

(A presentation of core imaging modalities with basic information of the technology each utilizes, the structures each visualizes, particularities and examples of research applications)

11.00 CET   MRI   (20’ – M Srinivas)

11.20 CET   PET-CT   (20’ – A Gaitanis)

11.40 CET   SPECT-CT   (20’- P Chaudhari)

Lunch break

13.20 CET   Fluorescence microscopy-based imaging techniques to study cellular and molecular events in preclinical animal models (20’ – M Francolini)

Animal Procedures (90’)

13.40 CET   Animal use projects: authorization, ethics and mouse biomethodology (70’ – A Zacharioudaki & TBA)

14.50 CET    Intravenous administration of compounds during dynamic imaging (20’ – E Balafas)


Day 2 (Tuesday 19/10/2021): Specific models Part 1

Rodent models for cardiac diseases (90’)

09.00 CET   Disease & models (20’ – I Mourouzis)

09.20 CET   Imaging applications (20’ – I Mourouzis)

09.40 CET   Animal procedures and humane endpoints (20’ – M Katsimpoulas)

10.00 CET   Ex vivo studies & sample processing (20’ – M Mavroidis)

Rodent models for neurological diseases (90’)

10.30 CET   Intravital imaging of brain inflammation with two-photon microscopy (20’ – D Thomaidou)

10.50 CET   Imaging applications in neurodegenerative diseases (20’ – V Kyrargyri)

11.10 CET   Animal procedures and humane endpoints (20’ – E Fragkiadaki)

11.30 CET   Ex vivo studies & sample processing (20’ – A Tsingotjidou)

Lunch break

Rodent models for liver diseases (90’)

13.00 CET   Disease & models (20’ – A Chatzigeorgiou)

13.20 CET    Animal procedures and humane endpoints (10’ – ΤΒΑ)

13.30 CET    Imaging applications (10’ – A Chatzigeorgiou)

13.40 CET   Ex vivo studies & sample processing (20’ – I Pateras)

Plenary lecture

14.30 CET  Animal welfare considerations and impact on imaging studies (30’ – J Lopez-Tremoleda)


Day 3 (Wednesday 20/10/2021): Specific models Part 2

Rodent models for oncology (90’)

09.00 CET   Disease & models (20’ – I GLADWYN-NG)

09.20 CET   Animal procedures and humane endpoints (20’ – L Whitfield)

09.40 CET   Imaging applications (20’ – V Ntafis)

10.00 CET   Ex vivo studies & sample processing (20’ – M Barbeck)

Rodent models of arthritis (90’)

10.30 CET   Disease & models (30’ – M Armaka)

11.00 CET   Imaging applications (20’ – M Dragolia)

11.20 CET   Experimental procedures and readouts of a spondyloarthritis model (30’ – E Christodoulou)

Lunch break

Rodent models for osteoporosis (90’)

13.00 CET   Disease & models (20’ – I Dontas)

13.20 CET   Animal procedures, humane endpoints, imaging applications (30’ – P Lelovas)

13.50 CET   Imaging applications, ex vivo studies & sample processing (30’ – E Douni)


Day 4 (Thursday 21/10/2021): Practices, Data and Applications

09.00 CET   Radiolabelling compounds for imaging and therapy (30’ – P Bouziotis)

09.30 CET   Image processing (45’ )

10.45 CET   Good Laboratory Practice (30’ – T Karampelas)

Coffee break

11.30 CET   Regulatory drug development (30’ – P Glerup)

12.00 CET   The next step: EMA/FDA applications (30’ – I Allen)

Lunch break

13.30 CET   Imaging in practice (preparation for the workshop) (30’ – I Pilatis)

14.00 CET   MCQ Test, Course evaluation and closure of theoretical part

Dinner night for all participants and speakers who reside in Attica


Day 5 (22 or 23/10/2021): Practical training,

Each participant attends one 3h session either on 22/10 or on 23/10.

Sessions: 09.00 – 12.00, 13.00 -16.00 (hours refer to ΕΕSΤ-Athens!)

        1. Mouse Workshop (90’ – AZ)
          1. Mouse handling – practice on live animals.
          2. Substance administration (iv, sc, ip, og) – practice on “mimicky” mouse.
        2. Imaging practice (90’ – RP)
          1. Simulation of use of anesthetic machine and anesthesia during imaging.
          2. CT, SPECT, β-eye, γ-eye imaging using the mouse phantom model.
          3. Post-processing examples.

Invited Speakers & Laboratories

Irving Allen, MBA, MS, PhD, President and Director of Research Consulting, Allen Consulting and Management


Marietta Armaka, PhD, Researcher C’ (equivalent to assistant professor level), BSRC “Alexander Fleming”


Evangelos Balafas, BSc, MSc, Senior LATG, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens


Mike Barbeck, PhD, Managing Director, BerlinAnalytix


Cyril Berthet, PhD, Pharmaco-imaging Unit Director, Oncodesign


Penelope Bouziotis, PhD, Research Director, Radiochemical Studies Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety INRASTES, NCSR “Demokritos”


Antonios Chatzigeorgiou, MD, PhD, Assistant Professor of Experimental Physiology, Department of Physiology, Medical School, National and Kapodistrian University of Athens


Pradip Chaudhari


Eleni Christodoulou, PhD, Biomedcode Hellas


Ismene Dontas, DVM, PhD, Professor of Experimental Surgical Research, Laboratory for Research of the Musculoskeletal System, School of Medicine, National and Kapodistrian University of Athens


Eleni Douni, Associate Professor, Department of Biotechnology, Agricultural University of Athens & Associate Researcher, Biomedical Sciences Research Center “Alexander Fleming”


Melina Dragolia, MSc, Technician, Animal Facilities BSRC “Alexander Fleming”


Eirini Fragkiadaki, DVM, MSc, PhD, Head of Laboratory Animals Facilities, Designated veterinarian, Department of Animal Models for Biomedical Research, Hellenic Pasteur Institute


Maura Francolini, PhD, Dept. of Medical Biotechnology and Translational Medicine, Universita degli Studi di Milano


Ivan E. GLADWYN-NG, B.Sc.(Med.), Ph.D. , Field Application Scientist, Regional Lead EMEA & APAC, Taconic Biosciences


Peter Glerup, DVM, MSc, Senior Director of Non-Clinical Safety Assessment, Zealand Pharma A/S


Theodoros Karampelas, PhD, Quality Assurance Manager, BIOEMTECH Laboratories


Michalis Katsimpoulas, DVM, SRS, PhD, Staff Research Scientist – Assistant Professor Level, Experimental Surgical Unit, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens


Vasiliki Kyrargyri, PhD, Independent Postdoctoral Researcher, ELIDEK fellow, Department of immunology, Laboratory of Molecular Genetics, Hellenic Pasteur Institute


Pavlos Lelovas, DVM, MSc, PhD, Designated Veterinarian, Laboratory for Research of the Musculoskeletal System, School of Medicine, National and Kapodistrian University of Athens


Jordi L.Tremoleda, DVM, PhD, FHEA, MRCVS, Named Veterinary Surgeon and Welfare Officer, Senior Lecturer in Trauma, Animal Science & Welfare, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London


George Loudos, PhD, Assistant Professor, Department of Biomedical Engineering, University of West Attica, Athens, Greece & CEO, BIOEMTECH Laboratories


Manolis Mavroidis, PhD, Investigator – Assistant Professor Level, Center of Basic Research, Biomedical Research Foundation Academy of Athens


Iordanis Mourouzis, Associate Professor, Dpt of Pharmacology, Medical School, National and Kapodistrian University of Athens


Vasileios Ntafis, DVM, MSc, PhD, Staff Scientist B’, Head-Designated Veterinarian, Animal Facilities BSRC “Alexander Fleming”


Ioannis Pateras, PhD


Irenaios Pilatis, Laboratory Engineer, BIOEMTECH Laboratories


Maritina Rouchota, PhD, Lab Manager & Application Specialist, BIOEMTECH Laboratories


Mangala Srinivas, PhD, FYAE, Professor and Head of Dept. – Chair Group Leader, Cell Biology & Immunology (CBI), Wageningen University & Research


Dimitra Thomaidou, PhD, Research Director, Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute


Anastasia Tsingotjidou, Associate Professor, Laboratory of Anatomy, Histology and Embryology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki


Lucy Whitfield, MA VetMB DLAS PGCert(VetEd) FHEA MRCVS, Director, OWL Vets Ltd


Argyro Zacharioudaki, DVM MLAS DiplECLAM, Veterinarian & In-vivo Research Consultant, BIOEMTECH Laboratories


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