Real-time, in vivo rodent imaging, allows researchers to observe and monitor several normal and abnormal biological processes. Data collected using the eyes series, provides crucial initial insights and generate quantitative results that, in combination with the Visual | eyesTM  interface, compose an essential platform for every preclinical laboratory.

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Oncology

Non-invasively assess your agent's targeting properties, real-time monitor drug delivery and track tumor progression.

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Infection, Inflammation

Acquire detailed insights into disease mechanisms, enhance more accurate diagnostics while supporting the development or improvement of new or already existing therapeutics.

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Protocol optimization

Test different animal preparation conditions, drug concentrations and administration routes to optimize your protocols.

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Quick insights

Scan the same mouse at multiple time points to determine the optimal moments for 3D imaging. Conduct super-fast QC to exclude faulty injected subjects from further and more complex studies.

Applications with eyes™

Oncology, BLI

Tumor imaging using a bioluminescent dye

This study demonstrates the use of D-Luciferin as a bioluminescence reporter in a non-orthotopic glioblastoma tumor model. Imaging was performed at day 3 and 10 after the inoculation of 1 million U87MG-Luc2 cells. Key parameters: injected concentration of 3 mg, injection volume of 200 μL saline and exposure time of 5 minutes.

Oncology, FLI

Evaluation and staging of Epidermoid Carcinoma

This case study highlights the use of fluorescence optical imaging for in vivo therapy evaluation and staging of Epidermoid Carcinoma (Squamous Cell Carcinoma) in preclinical models. RFP dyes were utilized to enable targeted imaging and enhance visualization of tumor dynamics.

Oncology, FLI

Tumor imaging using the φ-eye™

tdTomato, a constitutively fluorescent orange protein (excitation ~554 nm, emission ~581 nm), is utilized for tumor imaging applications. This example demonstrates its use in a neurofibroma model, with the dye administered intravenously to enable fluorescence-guided imaging.